Latent Space - Videos

🔬There Is No AlphaFold for Materials — AI for Materials Discovery with Heather Kulik

Materials science is the unsung hero of the science world. Behind every physical product you interact was decades of research into getting the properties of materials just right. Your gym clothes c...

Dreamer: the Agent OS for Everyone — David Singleton

David Singleton, the longtime former CTO of Stripe, has now launched Dreamer, a new consumer-focused platform to discover, build, and use AI agents and “agentic apps,” centered on a customizable pe...

Anthropic’s Felix Rieseberg on AI Coworkers, Local-First Agents, and the Future of Knowledge Work

From building Electron and helping ship the Slack desktop app to now shaping Claude Cowork at Anthropic, Felix Rieseberg has spent years working at the interface layer. In this episode, Felix joins...

⚡️Monty: the ultrafast Python interpreter by Agents for Agents — Samuel Colvin, Pydantic

https://github.com/pydantic/monty

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Eskildsen of Turbopuffer

From spending nearly a decade scaling Shopify’s infrastructure to doing “angel engineering” for companies like Readwise and Replicate, Simon Hørup Eskildsen went through the arc of getting haunted ...

OpenClaw's Memory Sucks and the fix is simple — Dhravya Shah, Supermemory

https://github.com/supermemoryai/openclaw-supermemory https://x.com/DhravyaShah/status/2023630749065228364

Agent Inference at the "Speed of Light" — How NVIDIA moves like a $4.3 Trillion Startup

Swyx and Vibhu chat with Nader Khalil (https://x.com/naderlikeladder) and Kyle Kranen (https://x.com/KranenKyle) from NVIDIA about NVIDIA'S DX mission - Brev’s origin as a one-click way to access G...

Why Your AI Agents Don’t Work with Dex Horthy of HumanLayer | In-Context Cooking

In this episode, we have Dex Horthy, founder and CEO of Humanlayer and the mind behind “context engineering,” joining us to recreate restaurant-style Dan Dan noodles. From his first internship at N...

Cursor's Third Era: Cloud Agents — ft. Sam Whitmore, Jonas Nelle, Cursor

https://cursor.com/blog/third-era Cursor Cloud Agents: Tested PRs, Demo Videos, Parallel Model Swarms, and the Future of Agentic Coding swyx catches up with Jonas and Sam in the beautiful new Cur...

Why Every Agent Needs a Box — Aaron Levie, Box

swyx and guest host Jeff Huber (CEO of Chroma, past guest!) chat with Aaron Levie, CEO of Box, on how AI agents will transform enterprise knowledge work and why companies must adapt workflows to ma...

⚡️ Polsia: Solo Founder Tiny Team from 0 to 1m ARR in 1 month & the future of Self-Running Companies

https://x.com/bencera_/status/2027825976261111966?s=20

Measuring Exponential Trends Rising (in AI) — Joel Becker, METR

Joel Becker explains METR’s focus on Model Evaluation and Threat Research to assess whether AI could pose enormous or catastrophic risks. Becker discusses METR’s publicized work such as the time ho...

Dylan Patel Explains the AI War While Cooking | In-Context Cooking

In this episode, we have Dylan Patel founder and CEO of SemiAnalysis joining us to recreate restaurant-style chicken fried rice. From semiconductor bottlenecks and Nvidia’s paranoia, to $200B hyper...

‘You guys are so inefficient’ #substack #shorts

This is a clip from https://www.latent.space/p/paid-anthropic-distillation-and-how?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=7EBQ04OL-is #shorts #substack

Privacy or policing? #substack #shorts

This is a clip from https://www.latent.space/p/paid-anthropic-distillation-and-how?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=7EBQ04OL-is #shorts #substack

How models memorize from one pass #substack #shorts

This is a clip from https://www.latent.space/p/paid-anthropic-distillation-and-how?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=7EBQ04OL-is #shorts #substack

🔬Max Welling: Materials Underlie Everything

In this episode recorded at NeurIPS 2025, Max Welling traces the intellectual thread connecting quantum gravity, equivariant neural networks, diffusion models, and climate-focused materials discove...

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

A special double pod on the 1 year anniversary of Claude Code: we chat with one of its most vocal fans, who thinks it will write 25-50% of all code on GitHub, plus get a breakdown on the memory cru...

The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals

Olivia Watkins (Frontier Evals team) and Mia Glaese (VP of Research at OpenAI, leading the Codex, human data, and alignment teams) discuss a new blog post (https://openai.com/index/why-we-no-longer...

Inside AI’s $10B+ Capital Flywheel — Martin Casado & Sarah Wang of a16z

From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at the center of the capital, compute, and tale...

The AI Frontier: from Gemini 3 Deep Think distilling to Flash — Jeff Dean

From rewriting Google’s search stack in the early 2000s to reviving sparse trillion-parameter models and co-designing TPUs with frontier ML research, Jeff Dean has quietly shaped nearly every layer...

🔬Generating Molecules, Not Just Models

This episode traces the remarkable journey from AlphaFold2’s landmark achievement in protein structure prediction to the broader landscape of molecular interaction modeling and protein design. The ...

⚡️ Reverse Engineering OpenAI's Training Data — Pratyush Maini, Datology

Should you add reasoning traces to your pretraining data? There’s been a surge of academic work speculating its advantages. But do frontier labs actually do this? Turns out, we can answer confident...

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

From Palantir and Two Sigma to building Goodfire into the poster-child for actionable mechanistic interpretability, Mark Bissell (Member of Technical Staff) and Myra Deng (Head of Product) are tryi...

⚡️Context Graphs: according to the authors — Jaya Gupta, Ashu Garg, Foundation Capital

In this Lightning pod, swyx hosts Jaya Gupta and Ashu Garg from Foundation Capital to discuss the emergence of context graphs. They define this new framework as the institutional memory of "the why...

🔬 From Red Teaming GPT-4 to Automating Drug Discovery: The Future of AI in Science — Andrew White

_Editor’s note: Welcome to our new AI for Science pod, with your new hosts RJ and Brandon! See the writeup on __Latent.Space_ (http://Latent.Space)_ for more details on why we’re launching 2 new po...

⚡️ Prism: OpenAI's LaTeX "Cursor for Scientists" — Kevin Weil & Victor Powell, OpenAI for Science

“2026 in AI for Science is going to look a lot like 2025 for Software Engineering” — Kevin Weil From building *Crixet* in stealth (so stealthy Kevin had to hunt down Victor on Reddit to explore an...

Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay

From shipping *Gemini Deep Think* and *IMO Gold* to launching the *Reasoning and AGI team in Singapore,* *Yi Tay* has spent the last 18 months living through the full arc of Google DeepMind's pivot...

Brex’s AI Hail Mary — With CTO James Reggio (acquired for $5B by Capital One!)

From building internal AI labs to becoming CTO of Brex, James Reggio has helped lead one of the most disciplined AI transformations inside a real financial institution where compliance, auditabilit...

Artificial Analysis: The Independent LLM Analysis House — with George Cameron and Micah Hill-Smith

don’t miss George’s AIE talk: https://www.youtube.com/watch?v=sRpqPgKeXNk —- From launching a side project in a Sydney basement to becoming the *independent gold standard for AI benchmarking*—trust...

[State of Research Funding] Beyond NSF, Slingshots, Open Frontiers — Andy Konwinski, Laude Institute

From co-founding *Databricks* and *Perplexity* to launching the *Laude Institute*—a dual venture fund and nonprofit designed to turbocharge the path from *research breakthrough to breakout company*...

[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang

From creating *SWE-bench* in a Princeton basement to shipping *CodeClash,* *SWE-bench Multimodal,* and *SWE-bench Multilingual,* *John Yang* has spent the last year and a half watching his benchmar...

[State of MechInterp] SAEs in Production, Circuit Tracing, AI4Science, "Pragmatic" Interp — Goodfire

From PhD research on grounding and language models to shipping interpretability tools in production at *Goodfire,* *Jack Merullo* and *Mark Bissell* are building the infrastructure to crack open th...

[State of AI Papers 2025] Fixing Research with Social Signals, OCR & Implementation — Team AlphaXiv

From late-night dorm-room hacking sessions at Stanford to building the most-used platform for navigating AI research, the founders of *AlphaXiv* have spent the last few years watching the archive f...

[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton

From undergraduate research seminars at Princeton to winning *Best Paper award at NeurIPS 2025,* *Kevin Wang, Ishaan Javali, Michał Bortkiewicz, Tomasz Trzcinski, Benjamin Eysenbach* defied convent...

[State of Context Engineering] Agentic RAG, Context Rot, MCP, Subagents — Nina Lopatina, Contextual

From neuroscience PhD research on reward learning and decision making to building the infrastructure for *context engineering at scale,* *Nina Lopatina* has spent the last year watching a brand-new...

[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena

_We are reupping this episode after LMArena announced their fresh Series A (_https://www.theinformation.com/articles/ai-evaluation-startup-lmarena-valued-1-7-billion-new-funding-round?rc=luxwz4_), ...

[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI

From pre-training data curation to shipping *GPT-4o,* *o1,* *o3,* and now *GPT-5 thinking* and the *shopping model,* *Josh McGrath* has lived through the full arc of OpenAI's post-training evolutio...

[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor

From Berkeley robotics and OpenAI's 2017 Dota-era internship to shipping RL breakthroughs on GPT-4o, o1, and o3, and now leading model development at *Cursor,* *Ashvin Nair* has done it all. We cau...

[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify

From investing through the modern data stack era (DBT, Fivetran, and the analytics explosion) to now investing at the frontier of AI infrastructure and applications at *Amplify Partners,* *Sarah Ca...

One Year of MCP — with David Soria Parria and AAIF leads from OpenAI, Goose, Linux Foundation

One year ago, Anthropic launched the *Model Context Protocol (MCP)*—a simple, open standard to connect AI applications to the data and tools they need. Today, MCP has exploded from a local-only exp...

Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE

Note: Steve and Gene’s talk on Vibe Coding and the post IDE world was one of the top talks of AIE CODE: https://www.youtube.com/watch?v=7Dtu2bilcFs&t=1019s&pp=0gcJCU0KAYcqIYzv From building legend...

⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI

From the frontlines of OpenAI's Codex and GPT-5 training teams, *Bryan* and *Bill* are building the future of AI-powered coding—where agents don't just autocomplete, they architect, refactor, and s...

Neural Nets My AI Pill Moment with Chris Olah

Unlocking the Immune System A Deep Dive into Biology

IIT India's Elite Engineering Schools Explained

Future of Doctors AI's Role in Healthcare

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

_as with all demo-heavy and especially vision AI podcasts, we encourage watching along on our YouTube (and tossing us an upvote/subscribe if you like!)_ From SAM 1's 11-million-image data engine to...

Supporting Python in AI Cloud

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

*Note: this is Pliny and John’s first major podcast. Voices have been changed for opsec.* From jailbreaking every frontier model and turning down Anthropic's Constitutional AI challenge to leading ...